Tumor necrosis factors

Tumor necrosis factor (TNF family) refers to a group of cytokines, its family can cause cell death (apoptosis). The first two family members to determine:
Tumor necrosis factor (TNF), formerly known as TNF-α, and this class is the most famous members. TNF is a monocyte-derived cell toxin, tumor regression, septic shock and cachexia, has been implicated. as a prohormone protein synthesis with abnormally long and atypical signal sequence, it is absent from the mature secreted cytokines . Briefly hydrophobic amino acid prohormone supply stretch to anchor in the lipid bilayer.  of the mature protein and the hormone in the form of local processing can be secreted after propeptide cleavage. 
Lymphotoxin alpha, formerly known as tumor necrosis factor-β (TNF-β) is a cytokine inhibition of interleukin-10.