TNF alpha

TNF was thought to be produced primarily by macrophages, but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neuronal tissue. Large amounts...

TNF is primarily produced as a 212-amino acid-long type II transmembrane protein arranged in stable homotrimers. From this membrane-integrated form the soluble homotrimeric cytokine (sTNF) is released via proteolytic cleavage by the metalloprotease TNF...

Tumor necrosis factor (TNF, cachexin, or cachectin, and formerly known as tumor necrosis factor-alpha orTNF-α) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate theacute phase reaction. It is produced...