Rhombencephalic neural crest of the signaling molecule BMP4-mediated apoptosis.

Pattern in the head region of the gill skeleton structure and muscle by neural crest1, its cells appear hindbrain the discrete segmental level chicks: specifically, Ling (R) L +2, r4 and r6 profound impact, andthe r3 and R5 crest depleted2. We have demonstrated that the to the, even Ling and R3/R5 affect the depletion of the neural crest, the interaction between the lead the discrete migration flow of nerve crest3 carving.Such a mechanism through increased expression of MSX2, R3 and R5 back induced apoptosis. Here, we show that, of BMP4 signaling molecule expressed in r3 and r5, is dependent on the neighboring Ling. The addition of recombinant BMP4 protein explants body R3 or R5 generated when the neural crest separated from their neighbors Ling, cultural upregulation of MSX2 and restore neural crest apoptosis population.