The 1.7 Å crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-blade

By virtue of its ability to complement hamster cell line tsBN2, it has undergone premature chromosome condensation or cell cycle arrest in G1 phase of the non-temperature-sensitive phenotype cloned genes encoded in chromosome condensation (RCC1) the Regulator license temperatures1 2. The RCC1 homologous genes have been identified in many eukaryotes, including the budding and fission yeast. Gene mutations will affect the messenger RNA processing and transport3 of, 4, mating5 start mitosis6 and chromatin decondensation7, RCC1 nucleocytoplasmic transport and cell cycle control is very important. Biochemical, RCC1 is a guanine nucleotide exchange factor nuclear Ras homologue Ran8, it increases the dissociation combined contingent of 105 times the gross domestic product (GDP) (see Section 9). It can also be combined with DNA, protein - protein complex2. Here, we show that the structure of the human RCC1 1.7Å resolution X-ray crystallography, by a 7-bladed propeller, each blade is formed from the internal repeat 51-68 residues. Repeat sequence and structure is different from those WD40 domain proteins, also form a 7-blade propeller, including the G protein subunit. Explain the nature of the structure of a wide range of known mutations consequences. A protein involved in the guanine nucleotide exchange region is located opposite the area is considered to be combined in the chromosome participation.